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Declarations Authors contributions Designed the paper, selected and prepared the references, prepared the figures, wrote the manuscript: Wright JW Prepared the references, wrote the manuscript: Harding JW Availability of data and materials Not applicable

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The CIS20r fatigue scale was 51 6 pretreatment and 50 6 posttreatment, and the CIS20r concentration scales were both 28 6 pretreatment and posttreatment

This peptides effect on dermal density and surface morphology positions it as a benchmark compound in cosmetic and dermatological research formulations