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[49] Ultimately, consumer use and sale of GLP-1 drugs indicates that consumers are often playing a very active role in choosing the drug, and are also communicating less with a physician, which are both reasons underlying why some states have recognized exceptions to the doctrine in other circumstances

In people of European descent, a much smaller but still significant fraction of the population (up to ~10-15%) carry the ABCG2 Q141K allele that causes renal urate transport functional impairment via ABCG2 dysfunction

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