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Inclusion of covariates in the final two-compartment model explained 58%, 56% and 24% of the interindividual variance of CL, volume of distribution and k a , respectively

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These come from megaloblastic anaemia, the type of anaemia caused by impaired production of healthy red blood cells

What happens if I can't tolerate the full 2.4 mg dose

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The D-alanine substitution at position 2 is specifically directed at blocking the primary DPP-4 cleavage site, while the remaining substitutions prevent additional enzymatic attack at susceptible positions and reduce oxidative degradation during storage and in vivo