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Discrepant findings in humans may be due to the short duration of the studies (on average 35 weeks) and the fact that fractures have not been considered a primary outcome in the studies, but rather, an adverse event [56], (Table 1)

56 The most common adverse events were gastrointestinal in the preclinical, phase1 and 2 trials similar to trials involving injectable GLP-1 agonists

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