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Using a high-throughput screening method with the viability of lymphocytes as the primary readout, two classes of antibiotics (tetracyclines and fluoroquinolones) were identified as robust radioprotectors, including Enoxacin 90

Mitochondrial YBX1 promotes cancer cell metastasis by inhibiting pyruvate uptake

N Engl J Med 314(23):14941497 Rocha JF, Vaz-Da-Silva M, Nunes T, Igreja B, Loureiro AI, Bonifcio MJ, Wright LC, Falco A, Almeida L, Soares-Da-Silva P (2012) Single-dose tolerability, pharmacokinetics, and pharmacodynamics of etamicastat (BIA 5453), a new dopamine -hydroxylase inhibitor, in healthy subjects

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doi: 10.1016/j.tranon.2020.100905 43 RaoMGaoCGuoMLawBYKXuY

Different to baseline, at 4 months NADPH associated with several metabolite of purine metabolism, such as hypoxanthine, inosine monophosphate (IMP), cyclic adenosine monophosphate (cAMP) and allantoin (Fig