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Am J Physiol Renal Physiol 2003;284:F1207F1215
Glutathione and Hypothyroidism: Restoring Redox Balance In hypothyroidism - whether autoimmune (Hashimoto's) or non-autoimmune - the reduced metabolic rate paradoxically also creates oxidative stress, through different mechanisms: *Reduced mitochondrial efficiency - slower metabolism generates more electron leakage and ROS per unit of energy produced *Impaired antioxidant enzyme activity - thyroid hormones regulate the expression of antioxidant enzymes including GPx and SOD
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In healthy states, the body has a ratio of GSH: GSSG of 30:1 up to 100:1
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