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Our meta-analysis aims to address this gap by systematically evaluating available evidence on these therapies, providing insights into their relative benefits and risks
Mann JF, Anderson C, Gao P, Gerstein HC, Boehm M, Ryden L, et al
As noted, endogenous GLP-1 has a very short half-life of 12 min because it is rapidly degraded by the enzyme DPP-4, which results in low systemic levels
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Initial concerns regarding the possible link between the use of GLP-1 RAs and the development of pancreatitis or pancreatic cancer have not been supported by the results of RCTs [53,54], or real-world data [29,55,56]
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