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Safety signals of special interest, including pancreatitis, gallbladder events, neoplasms, and suicidal ideation, were adjudicated by blinded expert committees
This study innovatively focuses on the mechanism by which FOXO4-DRI induces apoptosis in senescent endothelial cells, demonstrating that it functions by activating the p53/BCL-2/Caspase-3 signaling pathway to promote selective apoptosis of these cells
Treatment protocols must be designed and managed by a qualified healthcare practitioner
Ma B, Pan Q, Peppelenbosch MP
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