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39,43 In contrast, among HFpEF cohorts, semaglutide showed clinically meaningful benefits in non-diabetic and diabetic cohorts ( Table 1 )

Moreover, high sugar intake in obese patients increases serum urate and decreases the percent of uric acid to creatinine clearance, indicating a close association between hyperuricemia and a high sugar diet [79]

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The active ingredient in those drugs is tirzepatide, which like semaglutide acts on glucagon-like peptide-1 (GLP-1) hormone receptors, but also targets glucose-dependent insulinotropic polypeptide (GIP) receptors