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A comprehensive review of various studies demonstrates that leucine supplementation can enhance lean body mass, improve muscle strength and functionality, and promote the growth of type II muscle fibers, although the ramifications are most notable in individuals exhibiting suboptimal protein consumption
This leads to the cleavage and translocation of AIF from the mitochondrial intermembrane space to the nucleus, phosphorylation of the histone H2A family member H2AX, mitochondrial release of the death-inducing protein Smac/direct IAP-binding protein with low PI (DIABLO), and inhibition of the anti-apoptotic protein X-linked inhibitor of apoptosis (XIAP)
This results in a higher concentration of toxic metabolites, which then whittle away at your gut lining
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S., Velazquez, J
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