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** In subjects with severely impaired renal function or on dialysis, chronic oral administration of L-carnitine may cause accumulation of TMA and TMAO in the blood resulting in trimethylaminuria, a pathological condition characterized by a strong "fishy odor" present in the urine, breath and sweat of the patient

Slinics policy is to never prescribe off-label when a licensed alternative exists

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For example, it should be avoided by individuals with a personal or family history of medullary thyroid cancer or those diagnosed with multiple endocrine neoplasia syndrome type 2

Known as Sakel's technique, insulin coma therapy was a common treatment for schizophrenia until the late 1950s when it fell out of fashion (Marks 2018

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