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The short answer is: not in the way you might think

The evidence might be the relaxation noted in the aorta without endothelium ex vivo as opposed to the lack of relaxation directly on the 3-D model composed of vascular smooth muscle cells (unlike the effect of NO-donor sodium nitroprusside) [61]

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However, this slowed gastric emptying, combined with reduced food and fluid intake and potential dehydration, can lead to harder stools and reduced bowel movement frequency in susceptible individuals

This is the component that often makes researchers think beyond static tissue response and toward dynamic recovery processes

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