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Over time, this can increase your risk of dehydration

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The pentose phosphate pathway, through the action of transketolase (TK), converts ribose-5-phosphate to glyceraldehyde-3-phosphate (34, 37)

The degree of deterioration depends on baseline diabetes severity, duration of disease, beta-cell function, and effectiveness of replacement therapies

Their half-lives are 13 hours (LIRA) and 7 days (SEMA), allowing for daily and weekly subcutaneous administration, respectively, thanks to the structural modifications introduced.5,10 Effects on obesity and glycaemic control Both LIRA 3 mg and SEMA 2.4 mg have demonstrated a strong appetite-suppressing and satiety-promoting effect, as well as a delaying effect on gastric emptying.11,12 The SCALE programme highlighted the efficacy of LIRA 3 mg in reducing body weight and waist circumference13 and confirmed a reduction in HbA1c levels in individuals with diabetes, along with a decreased progression from prediabetes to diabetes after three years of treatment14 (Table 1)