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The peptides in the fitness world are signalling molecules : they tell cells to do something repair this tissue, release growth hormone, calm this inflammation, curb that appetite

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But early rheumatoid arthritis, psoriatic arthritis, and crystal arthropathies frequently get filed under "wear and tear," especially when imaging is equivocal and inflammatory markers aren't checked

This review aims to summarize the available evidence on this topic

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APN, anterior pretectal nucleus