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Both treatment approaches resulted in a mean weight loss at 52 weeks, with oral semaglutide treatment resulting in a mean weight loss from baseline of 3.8 kg and 4.7 kg in the treatment-policy estimand and trial-product estimand analyses, respectively

A phase 3 study (NCT04822181), which enrolled 1200 patients with biopsy-proven MASH and fibrosis, is currently ongoing to assess the benefit of OW subcutaneous semaglutide 2 mg in this setting 93

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The glucagon arm is the third lever: rather than only reducing energy intake through appetite, glucagon agonism raises energy expenditure and pushes the liver to mobilize stored fat

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Despite these promising results, Semaglutide benefits from long-term approval and well-established safety data