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Safety: There is insufficient evidence regarding safety in humans

[DOI] [PMC free article] [PubMed] [Google Scholar] 50.Dickson SL, Shirazi RH, Hansson C, Bergquist F, Nissbrandt H, Skibicka KP

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Evidence suggests that IFN- suppresses System Xc transcription by activating the JAK-STAT-IRF1 pathway, which depletes intracellular GSH stores, intensifies lipid peroxidation, and induces ferroptosis in various tumor and immune cells