Specifically, glutathione (GSH) depletion has been shown in animal models of temporal lobe epilepsy and human epilepsy patients
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AOD-9604 and GLP-1 agonists like Semaglutide or Tirzepatide work through fundamentally different mechanisms with very different efficacy profiles
In addition, in a new set of experiments, we used an alternative protocol: we first gave cilostamide, then added 100 nM nifedipine, and then added retatrutide