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Once-weekly administered tirzepatide proved to be both noninferior and superior in reducing glycosylated hemoglobin levels in T2DM patients and demonstrated robust weight loss in obese patients [27,28]

10.1167/tvst.8.4.23 75 VukojevicJ.SiroglavicM.KasnikK.KraljT.StancicD.KokotA.et al (2018)

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Signs that dehydration is significant include dark urine, extreme thirst, dry mouth persisting despite drinking, or dizziness upon standing