can glp 1 cause allodynia is being reported with GLP-1 medications, It is a heightened sensitivity to touch that feel like pain. We are seeing it more at higher doses, The important point is that it appears Frontiers | The immunomodulatory effects

Weight loss reduces metabolic rate and subcutaneous fat insulation, leading to increased cold sensitivity through adaptive thermogenesis

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Financial support and sponsorship This work was supported by Fondo de Investigacin Sanitaria-FEDER (PI25/00528) and CIBEROBN from the Spanish Instituto de Salud Carlos III, and the Department of Health of the Gobierno de Navarra (GN2025/52)

Figures Abstract Glucagon-like peptide-1 (GLP-1) released from intestinal L cells in response to nutrients has many physiological effects but particularly enhances glucose-dependent insulin release through the GLP-1 receptor (GLP-1R)