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Thiazolidinediones mainly improve adipose tissue insulin sensitivity

However, our understanding of the function of GLP-1RAs is not complete, and further research, including long-term and large clinical trials are warranted to properly evaluate the causal relationship between GLP-1RAs and the development and progression of various cancers

Endocrinology 155 (4), 12801290

Both the injections and pills have similar side effects, including nausea, constipation, vomiting, gallbladder disease, and other gastrointestinal issues

GLP-1s increased the risk for thyroid C-cell tumors in studies of lab rats, but whether they cause these cancers in humans is unknown

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