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The metabolic enzyme CYP2E1 metabolizes APAP into the toxic intermediate N-acetyl-p-benzoquinone imine (NAPQI), which contributes to toxicity during APAP overdose

The research findings highlight the absence of a connection between clinical benefits and short-term cost savings, with the study authors concluding: "Our 24-month analysis did not demonstrate cost savings, in contrast to industry-sponsored models that project long-term savings (eg, over 10 years) based on trial-derived effectiveness. There have been fewer studies focused on the more recently approved tirzepatide-based drug Zepbound

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