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Int Immunopharmacol 53:2432 Lima Giacobbo B, Doorduin J, Klein H, Dierckx R, Bromberg E, de Vries E (2018) Brain-derived neurotrophic factor in brain disorders: focus on neuroinflammation

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Ex vivo rectal tumour samples more accurately reflect the dynamic tumour microenvironment, the complex architecture of the tumour, and the inherent genetic diversity between patients and therefore, this data supports metformin as a metabolic modulator in rectal tumours