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The progression of CKD can lead to end-stage renal disease (ESRD), increasing the risk of kidney failure with a need for renal replacement therapy involving dialysis or renal transplant

Pfeifer KJ, Selzer A, Mendez CE, et al

The NHS recommends an intake of approximately 1.5g per day of B12 for adults via diet or supplementation

[DOI] [PMC free article] [PubMed] [Google Scholar] 68.Wang Y, Chen D, Xie H, Jia M, Sun X, Peng F, et al

Signs You Might Need More B12 If the fatigue you're experiencing has a B12 component, the signs tend to cluster in recognizable patterns

These medications include certain types of antibiotics, diuretics, and anti-inflammatory drugs