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doi: 10.1007/s12603-021-1624-4 135 JoyceE

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As with other incretin receptor agonists, the most frequently reported side effects of retatrutide in clinical trials were gastrointestinal in nature , and were most pronounced during the dose escalation phase

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Immunohistochemistry of liver sections showed CD36 as located in the hepatocyte plasma membrane in patients with steatosis and NASH, compared to a weak CD36 expression confined to the cytoplasm of hepatocytes in normal livers, suggesting that the translocation of CD36 protein from cytoplasm to membrane may be a triggering event in NAFLD progression [25]

This interaction tends to happen when trazodone is in the antidepressant dose range, like 300 mg and above