Using the semaglutide salt has a greater potential for drug instability and variability which can increase the risk of adverse effects or therapeutic failure
This difference was unavoidable given the injection volume per increment for the 1.5-mL PDS290 pen injector, as the semaglutide concentration in IcoSema was 2 mg/mL, while the only semaglutide product available in China at the time of study conduct had a semaglutide concentration of 1.34 mg/mL
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Prioritizing protein, micronutrient-dense vegetables, and healthy fats over processed foods becomes critical
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