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Research confirms that GH enhances mitochondrial oxidative capacity in skeletal muscle, with 16-35% increases in ATP production rate and citrate synthase activity, directly supporting the tissue's ability to utilize mobilized fatty acids as fuel

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Moresco RN, Bochi GV, Stein CS, De Carvalho JA, Cembranel BM, Bollick YSJCca

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ERK1/2 kinases serve as central integration points for multiple cellular signaling pathways, including growth factor receptors, cytokine signaling, and stress-activated protein kinases that respond to oxidative damage, inflammatory mediators, and metabolic perturbations

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