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Unlike many experimental NRF2 activators (e.g., synthetic electrophiles or natural compounds like sulforaphane), DMF has undergone extensive Phase III trials, demonstrating its efficacy and safety in humans

Oxidative stress-involved mitophagy of retinal pigment epithelium and retinal degenerative diseases

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The mechanisms already discussed, including enhanced angiogenesis, increased fibroblast activity, collagen synthesis upregulation, and improved cell migration, all contribute to faster resolution of tissue damage

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NAC contains a free thiol group capable of breaking the stubborn disulfide bonds that hold microclots together