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The two-receptor approach is studied because GHRH and GHS-R1a signaling activate complementary but distinct intracellular pathways GHRHR primarily through Gs/cAMP/PKA, GHS-R1a primarily through Gq/PLC/IP3/Ca making the dual-agonist approach a useful research tool for studying somatotrope cell biology comprehensively

It is derived from a fragment of adrenocorticotropic hormone (ACTH) with an added Pro-Gly-Pro tail for stability, and is most commonly studied as an intranasal nootropic and neuroprotective peptide

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