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but lower doses led to more modest weight loss:Lower doses had a more favourable side effect profile, too:This triple agonism aims to relieve some of the side effects of GLP1s (nausea, muscle loss), and increase weight loss (so the dose can be lowered)Sources: New obesity drugs - nature.com/articles/d4158 Triple agonist Retatrutide phase 2 trial - nejm.org/doi/full/10.10 full article: openread.academy/en/paper/readi Breakdown of the article: The article discusses the development of new obesity drugs that aim to provide greater and healthier weight loss

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Contrarily to the other methods listed before, vaccine-based approaches do not only aim to target senescent cells in tissues, but also senescent immune cells, which can be responsible for age-related diseases 60

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doi: 10.1007/BF02124046 90