Individual trials have assessed the clinical profile of tirzepatide vs different comparators
De Souza, J
Creating the correct lens will take a combination of different of services to give a true picture, and it will not be a one size fits all approach starting with a comprehensive set of data assets, including prescription data, claims data, longitudinal prescription data (LRx), and services such as IQVIAs LAAD and MIDAS data
Concerns about the potential association between certain diabetes medications and cardiovascular disease meant that in 2010 the FDA approved liraglutide on condition that Novo Nordisk conduct a post-marketing study to evaluate the drug's effect on the incidence of major cardiovascular events (Nielsen, DeChiaro, Goldman)
It also delays gastric emptying, inhibits glucagon release from pancreatic alpha cells, causes the proliferation of beta cells, and decreases their apoptosis
1 Smaller amounts of GLP-1 are also produced by neurons in the nucleus tractus solitarius (NTS) of the brainstem, thus highlighting its dual role in both peripheral and central metabolic regulation
