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Reactive oxygen species induce Cox-2 expression via TAK1 activation in synovial fibroblast cells

2022 May James S Graydon, Karla Claudio, Seth Baker, Mohan Kocherla, Mark Ferreira, Abiel Roche-Lima, Jovaniel Rodrguez-Maldonado, Jorge Duconge, Gualberto Ruao

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In the chronic toxicity experiment, L-NAME caused severe tissue damage (myocardial and hepatic cell necrosis, necrosis of the lymphoid cells in the spleen) while L-arginine provoked predominantly congestion, edema and hemorrhages in all organs

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