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Combining them doubles GI side effects (nausea, gastroparesis risk) with no additional benefit

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Tralokinumab-ldrm and lebrikizumab-Ibkz block the effects of IL-13 only

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Further, we clarify that if a hospital has encoded a payer-specific negotiated charge in the MRF as a dollar amount, and that dollar amount represents the full payer-specific negotiated charge that is not further modified by a percentage or algorithm, the hospital would not be required to encode the allowed amounts

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Packaging payment for these drugs and biologicals that appear on a hospital outpatient claim with a primary C-APC service is consistent with our C-APC packaging policy under which we make payment for all items and services, including all non-pass-through drugs, reported on the hospital outpatient claim as being integral, ancillary, supportive, dependent, and adjunctive to the primary service and representing components of a complete comprehensive service, with certain limited exceptions (78 FR 74869)

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This formulation aligns with repeated-access vial management, maintaining an observed multi-use handling window of 28 days for documented research-use protocols

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