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(Wow, way to be dramatic, DNA.) While some people can shed smaller amounts of weight solely via lifestyle tweaks like eating less, moving more, and getting more sleep-about 5 to 10% of ones baseline weight, or about 9 to 18 pounds for a 175-lb persononly a tiny percentage of us can successfully lose larger amounts of weight using these strategies alone

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A key factoror lack thereofin this is the pharmaceutical companies, which are not exactly jumping on board to fund these very expensive studies