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When oxidative stress causes excessive generation of oxygen free radicals, keap1 protein releases Nrf2 through the release of zinc ions, followed by the entrance of Nrf2 into the nucleus to bind to the ARE anti-oxidative stress element sequence, and activates gene transcription downstream of the ARE region, which then initiates the oxidative stress response and reduces the oxidative stress

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Cell Stem Cell 7(4):483495

Every minute it spends at room temperature is a minute it's degrading faster than it needs to

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Puglisi R, Maccari I, Pipolo S, Conrad M, Mangia F, Boitani C