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While the exact reasons remain unclear, the increase is thought to be driven by several factors, including a higher prevalence of modifiable risk factors, such as excess body weight, physical inactivity, and exposure to environmental pollutants

In the STEP-1 clinical trial extension, participants regained about two-thirds of the weight they had lost within a year of stopping semaglutide

Manufacturer savings cards may be available, but for comprehensive weight management solutions, working with Klinic's prescription services for medications like Zepbound provides an insurance-friendly alternative

Current Opinion in Cell Biology

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Participants self-administered daily subcutaneous injections of tesamorelin (Theratechnologies Inc), a stabilized analog of human GHRH (1 mg/d), or a placebo 30 minutes before bedtime for 20 weeks