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But now after a few weeks I can really see the difference where the weight has finally started shifting from my upper and lower tummy region

& Michalsson, K

First, the effect is selective: visceral fat fell, but pinchable fat and total weight barely changed

Semaglutide medications work by activating the GLP-1 receptor alone, while tirzepatide medications activate both the GLP-1 receptor and the glucose-dependent insulinotropic polypeptide (GIP) receptor, creating what is commonly described as a dual incretin mechanism

These findings are in agreement with Sexton and Maize study (15)

(2024) Adipocentric Perspective of Pancreatic Lipotoxicity (Review)