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The safety implications of receptor desensitization include possible changes in the dose-response relationship over time and the possibility that higher doses may be needed to achieve similar effects in long-term protocols

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On the other hand, an immune response was observed at the 0 h time point under LPS treatment, demonstrated by the significantly increased activity of the five enzymes relative to their constituent values

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PMID: 145 BryantRVTrottMJBartholomeuszFDAndrewsJM