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The cystic fibrosis transmembrane conductance regulator (CFTR) in the endometrial epithelial cells transports chloride ions from the cytosol to the uterine lumen, which is crucial for maintaining uterine fluid homeostasis and regulating apoptotic activity of endometrial epithelial cells, all critical for embryo implantation
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Capaldo B, Napoli R, Di Bonito P, Albano G, Sacc L
This analgesic effect observed in vivo is likely underlain by liraglutides concerted anti-inflammatory action, as demonstrated in vivo in a mouse model of MIA, whereby liraglutide improves synovitis severity score, and also in vitro , whereby liraglutide dose-dependently decreased PGE 2, nitric oxide (NO), and IL-6 secretion, along with iNos , Cox2 , and Tnf- gene expression levels in both chondrocytes and macrophages