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Of note, toxicity can occur at serum concentrations that are lower than expected because LAs accumulate in mitochondria and cardiac tissue at a ratio of about 6:1 (or greater) relative to plasma
Freezing permanently damages semaglutide and destroys the peptide's structure, making it ineffective for weight loss
Uneven injection spacing can lead to irregular results
In addition, pregnant women, infants and children may require different dosages
PMID 16889122
Afr J Pharm Pharmacol 10(32):657664 Kahrilas PJ (2003) GERD pathogenesis, pathophysiology, and clinical manifestations
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