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Some patients maintain weight loss with lifestyle changes alone

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The jump from 5 mg to 10 mg produces substantial additional efficacy

This is not merely additive: the MOTS-c may amplify or extend the mitochondrial biogenesis signal beyond what training alone achieves, particularly in older adults whose endogenous MOTS-c response to exercise is blunted [2]

In SURMOUNT-1 (NEJM 2022, 2,539 adults with obesity), the 15 mg arm averaged 22.5% body weight loss at 72 weeks, the 10 mg arm 21.4%, and the 5 mg arm 16.0%