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Leptin binds to OB-Rb and activates the receptor-associated kinase JAK2 via transphosphorylation and phosphorylates three tyrosine residues (Y985, Y1077, and Y1138 in mice)

some pharmacokinetic data suggest slightly faster absorption from the abdomen, but the difference is not clinically meaningful

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Increased levels of hydrogen peroxide can lead to the depletion of intracellular adenosine triphosphate (ATP) and potentially lead to cell death [43]