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Conversely, animals treated with semaglutide in the HFD SEMA group showed an increased number of cells per hippocampal thickness, suggesting the treatment's efficacy in these animals

If the mechanism is fairly focused but the dosing schedule is poorly chosen, the observed effects may reflect protocol strain, cumulative exposure patterns, or handling inconsistencies rather than the peptides intended pharmacology

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Mechanism position

This binding sequesters semaglutide in the circulating pool, protects it against glomerular filtration and enzymatic degradation, and creates an effective depot that gradually releases the peptide to target tissues