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FDA-approved medications have undergone extensive clinical trials demonstrating safety and effectiveness for specific indications, with ongoing FDA oversight of manufacturing quality

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Descriptions and sources of reagents and detailed methods of our mouse models of experimental MI in vivo (66), IRI in vivo (67), IRI ex vivo (4, 21), as well as mouse and human cellular injury models in vitro (21, 68) are provided in the Supplemental Methods

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