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GHK-Cu, while not primarily "cleared" through hepatic metabolism in the traditional sense, introduces exogenous copper that is entirely dependent on hepatic processing and biliary excretion

Injectable GHK-Cu is more powerful and cost-effective than topical, but topical serums (1-2% concentration) work well for facial skin when applied daily

For example, certain blood pressure medications[3] and heartburn medications[4] can decrease magnesium absorption

Drugs 78:15491566

The cytotoxic effects of these copper compounds on HaCaT cells were observed to be concentration-dependent and time-dependent at concentrations 580 M and 5800 M

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