Clinical studies show that patients typically lose 10-20% of their body weight over several months with GLP-1 therapy
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The evidence base is anchored by STEP (semaglutide for weight management, The New England Journal of Medicine , 2021), SURMOUNT (tirzepatide for weight management, NEJM 2022), and SURMOUNT-OSA (tirzepatide for obstructive sleep apnea, NEJM 2024)
A significant degree of fibrosis was observed in liver tissues of control mice at 3 weeks, whereas GSTM2 -overexpressing mice showed mild fibrosis at 8 weeks (Supplementary Fig
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The safety of combining cagrilintide and tirzepatide has not been extensively studied in clinical trials
