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The strongest data comes from Harshini Neelakantan, Stan Watowich, and colleagues at the University of Texas Medical Branch (UTMB)

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Side Effects and Safety Gastrointestinal, heart-rate, and stomach-emptying effects are coupled to dose and titration speed

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351,352 The DNA oxidative damage and protein oxidation in the aged human brain are associated with declined antioxidant enzyme activities

The practical implication is that GHK-Cu addresses structural skin aging (collagen loss, elasticity decline) while neurotransmitter-modulating peptides address dynamic wrinkles (expression lines)