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This is the phase where the synergistic effects become most apparent

Increased plasticity has been shown to facilitate protease-independent migration of breast cancer cells by promoting the formation of invadopodia protrusions, which in turn generate contractile forces to create migratory paths for the cells [144]

It also varies with the activity of PC synthase (PCS, -Glu-Cys transpeptidase), a PC synthesizing enzyme (Fig

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Lancet 358 , 17541759 (2001)