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Conflict of interest The authors declare that the review was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest

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Participants were allocated in a 21:3:3:7 ratio to weekly injections of one of four regimens: fixed-dose cagrilintide 2.4 mg plus semaglutide 2.4 mg, semaglutide alone, cagrilintide alone, or placebo