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IGF-1 LR3 activates IGF-1 receptors and initiates the PI3K/Akt/mTOR cascade - the primary regulatory pathway responsible for muscle hypertrophy, protein synthesis, and tissue repair

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PMID: 17241888

However, novel promising combination therapies are being developed, including those that couple immunomodulators with drugs that stimulate -cell regeneration in order to restore normoglycaemia

it acts together with endothelial nitric oxide synthase (eNOS) and an increase in the availability of nitric oxide (NO), which dilates vessels and improves microcirculation

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