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Hypoxic regions are common in H&N SCC and may be related with resistance to ionizing radiation (61)

Regular monitoring of fasting glucose, fasting insulin, HOMA-IR, and HbA1c is suggested to monitor changes and refine dosing or lifestyle plans

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Tirzepatide dosage Healthcare providers typically start patients on a low tirzepatide dosage as the body adjusts to the medication to reduce side effects

These alternate metabolic routes lead to accumulation of toxic intermediates and advanced glycation end products, promoting inflammation, cellular dysfunction, apoptosis, and fibrosis within kidney tissues [24,25]